The role of CoQ10 in periodontal health

Coenzyme Q10 (CoQ10) is an important molecule for cellular health. It is also known as ubiquinone due to its strong presence in the human body. CoQ10 has many roles in human health. CoQ10 supports the body’s response to oxidative stress and cell membrane stability. It also helps stabilize calcium channels and plays an essential role in the production of cellular energy. Research indicates that CoQ10 may also help support periodontal health.

Periodontal health refers to the structures surrounding the teeth that include the gums and the bones that support the teeth. Periodontal disease is often associated with infection and an inflammatory response. This disease can also involve age-related changes. Periodontal disease affects about 90% of people over 65. One of the biggest threats to dental health is periodontal disease, according to the Centers for Disease Control.

Cellular energy production and metabolism have been shown to be important for the repair and healing of periodontal tissue. Some CoQ10 deficiencies have been linked to periodontal disease. Increased concentrations of CoQ10 have been reported in studies to support the body’s response to inflammation in the presence of diseased gum tissue. CoQ10 is believed to promote health through its ability to influence lipid peroxidation, help regenerate vitamin E from the alpha-tocopheroxyl radical, and interact with certain hydrogen peroxide molecules bound to mitochondrial DNA. .

A 4-week, randomized, controlled clinical trial evaluated the effectiveness of applying a gel containing CoQ10 to people with periodontal disease. Objective parameters were collected at weeks 2 and 4. Study results showed significant improvement at week 4 in some markers, including plaque index, gum index, and gum bleeding. The authors note that the study sample size was relatively small and that future studies should be conducted in larger populations with a substantial follow-up period.

Another randomized controlled trial explored the effectiveness of the application of CoQ10 on the oral health of smokers. Smoking is a known risk factor for periodontal disease. Smokers may also experience a reduced response to periodontal treatment compared to non-smokers. In the study, CoQ10 was delivered locally for a period of 3 months. The results of the study indicated a statistically significant improvement in mean plaque index scores. An overall improvement in all clinical parameters was also observed at the end of the 1 month and 3 month periods. As in the previously reported study, the sample size was also relatively small.

CoQ10 supports cell function and health in several ways. It supports cellular energy production and can support the body’s response to oxidative stress. Studies indicate that CoQ10 can promote changes in the gums and other structures related to periodontal health.

By Colleen Ambrose, ND, MAT


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